What is the most commonly used aminoglycoside for endocarditis and meningitis treatment in infants?

Gentamicin is the most commonly used aminoglycoside for the treatment of endocarditis and meningitis in infants due to its efficacy against a broad range of Gram-negative and some Gram-positive bacteria. It is particularly significant in treating serious infections in pediatric populations, where its use is well-supported by clinical guidelines.

In the context of endocarditis, gentamicin is often used in synergy with other antibiotics, such as penicillin or vancomycin, to effectively target the pathogens involved in this condition. The ability of gentamicin to achieve high concentrations in both serum and tissue makes it a preferred choice in serious systemic infections.

For meningitis, treatment regimens frequently incorporate gentamicin, especially when empirically treating suspected bacterial meningitis in infants. Its desirable pharmacokinetic properties allow for adequate penetration into the central nervous system, making it effective against causative organism strains that might pose a significant risk in young patients.

The other aminoglycosides listed, while effective in different scenarios and infections, are not the preferred choices for these specific conditions in infants. Tobramycin is often used for respiratory infections, notably in cystic fibrosis patients, but it is not the first choice for endocarditis or meningitis. Strept