What is the preferred route of administration for penicillin V?

The preferred route of administration for penicillin V is oral. This is due to its stability in gastric acid, which allows for effective absorption when taken by mouth. Penicillin V is designed for outpatient treatment of mild to moderate infections, where oral administration is both practical and convenient. Oral dosing allows patients to take the medication at home, facilitating adherence to the treatment regimen without the need for medical supervision or the discomfort associated with injections.

In contrast, other routes such as intramuscular or intravenous administration are typically reserved for certain penicillins that don't have the same pharmacokinetic properties or for specific clinical situations where immediate systemic absorption is necessary, such as severe infections. Subcutaneous administration is less common for penicillin V and is generally not utilized for this type of antibiotic due to potential absorption issues and discomfort. Therefore, oral administration is the most appropriate and widely accepted method for delivering penicillin V.