What toxicity is associated with Isoniazid treatment?

Isoniazid is an antibiotic primarily used for the treatment and prevention of tuberculosis. One of the significant adverse effects associated with its use is hepatotoxicity, which is the potential for the drug to cause liver damage. This toxicity can manifest as elevated liver enzyme levels, leading to conditions such as hepatitis, especially in certain populations like individuals who consume alcohol, those with pre-existing liver disease, or pregnant women.

The mechanism behind isoniazid-induced hepatotoxicity involves its metabolites and the formation of reactive intermediates, which can harm liver cells. Monitoring liver function tests during therapy is important to detect this side effect early.

While other options such as nephrotoxicity, ototoxicity, and cytotoxicity may pertain to different drugs or conditions, they are not the primary concerns associated with isoniazid treatment. Thus, the correct association in this case is with hepatotoxicity.