What type of infections are first generation cephalosporins primarily used to treat?

First-generation cephalosporins are primarily effective against gram-positive bacteria and have some coverage for gram-negative organisms. Their spectrum of activity makes them particularly useful in treating skin and soft tissue infections. This class of antibiotics is often employed for conditions such as cellulitis, impetigo, and surgical prophylaxis in clean surgical procedures involving potential skin flora.

While first-generation cephalosporins may have some roles in urinary tract infections and respiratory infections, their primary indication and strongest effectiveness lie in managing skin infections. This is due to their activity against common skin pathogens, such as Staphylococcus and Streptococcus species. The use in respiratory or gastrointestinal infections is not as prominent, as other classes of antibiotics are generally preferred in those cases due to differing bacterial profiles.