Which drug class should be avoided in athletes and pregnant women due to the risk of tendonitis?

Fluoroquinolones are a class of antibiotics that have been associated with an increased risk of tendonitis and tendon rupture, particularly in certain populations such as athletes and pregnant women. This concern is rooted in studies that have indicated that the use of fluoroquinolones can lead to adverse effects on connective tissues, especially the tendons. The mechanism behind this involves the ability of fluoroquinolones to interfere with the synthesis and repair of collagen, which is essential for maintaining tendon integrity.

For athletes, the risk of developing tendon injuries can significantly impact performance and lead to long-term consequences in their physical health. Similarly, for pregnant women, the potential risks involved in tendon damage during a time when maintaining physical health is crucial further underscores the need to avoid this drug class.

In contrast, the other drug classes mentioned do not have significant links to tendonitis as a major concern. Penicillins, aminoglycosides, and macrolides are generally considered safe and do not carry the same risks regarding tendon health. Therefore, fluoroquinolones stand out as the drug class that requires caution in these specific populations.