Which macrolide is often given as a single dose for treating chlamydial urethritis?

Azithromycin is the macrolide commonly prescribed as a single dose for the treatment of chlamydial urethritis. Its effectiveness in treating this infection stems from its ability to rapidly eliminate Chlamydia trachomatis, the bacterium responsible for the condition. The single-dose regimen is particularly advantageous for patient adherence and convenience, making it a preferred option in outpatient settings.

In contrast, erythromycin and clarithromycin are effective against Chlamydia but typically require multiple doses, which can impact compliance. Fidaxomicin, while an antibiotic, is primarily used for treating Clostridium difficile infections and is not indicated for chlamydial infections. Therefore, azithromycin stands out as the most appropriate choice for this specific treatment protocol.