Which of the following drugs is used topically to prevent or treat burn infections?

Silver sulfadiazine is specifically formulated for topical application and is widely used in clinical practice to prevent or treat infections in burn wounds. This antimicrobial agent combines the properties of silver, known for its broad-spectrum antibacterial effects, with sulfadiazine, which is effective against various bacteria, including both gram-positive and gram-negative strains. This combination not only helps to prevent the growth of bacteria but also promotes healing by providing a moist environment conducive to wound recovery.

The use of silver sulfadiazine is particularly beneficial in burn injuries, as the skin's protective barrier is compromised, making it more susceptible to infections. The drug's application creates a protective layer over the wound, thereby minimizing the risk of microbial colonization and subsequent infection, which can lead to severe complications in burn patients.

In contrast, the other options provided are primarily systemic antibiotics or are used for different therapeutic purposes. For instance, trimethoprim-sulfamethoxazole is generally utilized for treating urinary tract infections and certain bacterial infections but is not intended for topical application. Rifampin is mainly used for treating tuberculosis and some other serious bacterial infections and is also not indicated for topical use on burns. Isoniazid, similarly, is an antibiotic used primarily to treat tuberculosis and