Who is most at risk of seizures when treated with Carbapenems?

Patients with epilepsy are particularly at risk of experiencing seizures when treated with Carbapenems. This increased risk is due to the potential for these antibiotics to alter the seizure threshold. Carbapenems, while generally safe and effective, can lead to central nervous system side effects, including seizures, particularly in individuals who have a history of seizure disorders such as epilepsy.

Patients with epilepsy are already susceptible to seizures, and the introduction of a medication that can provoke seizures can exacerbate their condition. The risk is particularly pronounced in this population because of their underlying neurological vulnerability.

Other groups, such as those with hypertension or pregnant women, do not have the same direct association with seizure risk in the context of Carbapenem treatment. While athletes may experience various health issues, their risk related to seizures specifically tied to Carbapenem use does not compare to that of individuals with epilepsy. Thus, patients with epilepsy are the most relevant and at-risk group concerning the side effects of Carbapenems.